Older people are at higher risks of toxicity for any given dose. About 1% of those with an acute overdose die, while chronic overdoses may have severe outcomes. In 2004, more than 20,000 cases with 43 deaths were reported in the United States. The toxic effects of salicylates have been described since at least 1877. If a person requires intubation, a fast respiratory rate may be required. Dialysis is recommended in those with kidney failure, decreased level of consciousness, blood pH less than 7.2, or high blood salicylate levels. Giving dextrose may be useful even if the blood sugar is normal. Treatment may include activated charcoal, intravenous sodium bicarbonate with dextrose and potassium chloride, and dialysis. Įfforts to prevent poisoning include child-resistant packaging and a lower number of pills per package. In overdose maximum blood levels may not occur for more than 12 hours. While a type of graph has been created to try to assist with diagnosis, its general use is not recommended. Diagnosis is generally based on repeated blood tests measuring aspirin levels and blood gases.

Small amounts of oil of wintergreen can be toxic. Excess doses can be either on purpose or accidental. While usually due to aspirin, other possible causes include oil of wintergreen and bismuth subsalicylate.

Complications can include swelling of the brain or lungs, seizures, low blood sugar, or cardiac arrest. Early on, these may be subtle, while larger doses may result in fever. The classic symptoms are ringing in the ears, nausea, abdominal pain, and a fast breathing rate. Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. Swelling of the brain or lungs, seizures, low blood sugar, cardiac arrest Įarly: Slightly elevated blood aspirin levels ~ 2.2 mmol/L (30 mg/dL, 300 mg/L), respiratory alkalosis Ĭhild-resistant packaging, low number of pills per package Īctivated charcoal, intravenous sodium bicarbonate with dextrose and potassium chloride, dialysis Ringing in the ears, nausea, abdominal pain, fast breathing rate

Salicylism, salicylate toxicity, aspirin poisoning, aspirin toxicity, aspirin overdoseĪ skeletal structural formula for aspirin.

Aspirin toxicity antidote